ARI Crystal Gryphon
Equipment overview
The Crystal Gryphon is a compact automated liquid handler designed specifically for protein crystallization screening and optimization.
It is engineered to dramatically speed up crystallization trials—capable of setting up and sealing a complete 96-well vapor diffusion plate in under a minute. A primary feature of the Gryphon series is that it operates entirely without disposable tips, utilizing positive-displacement glass syringes and non-contact micro-dispensing heads to substantially lower operating costs and reduce environmental waste.
Major applications
Sitting Drop, Hanging Drop, and Microbatch Assays: Sets up traditional vapor diffusion and batch crystallization trials rapidly.
Lipid Cubic Phase (LCP): Handles viscous membrane protein crystallization setups (in specialized LCP configurations).
Bicelle and Sponge Phase Screening: Dispenes specialized media used for membrane protein structures.
High-Throughput Screening & Optimization: Rapidly fills screening reservoirs and sets up multi-well optimization plates
Specifications
- • Dispense Volume Range
- Down to 25–50 nl (depending on configuration) up to 100 µl
- • Pipetting Heads
- Features a 96-channel positive displacement syringe head (tip-less design to reduce waste) for buffers, paired with a non-contact single-channel (or multi-channel) nano-dispenser for proteins.
- • Speed
- Sets up and seals a complete 96-well plate in under 1 minute to prevent sample evaporation
- • Plate Formats
- Compatible with standard 24-, 96-, and 384-well crystallization plates and Intelli-plates.