Bruker timsTOF MALDI-2 with nanoElute System
Equipment overview
Bruker timsTOF MALDI-2 Trapped Ion Mobility Spectrometry - Quadrupole Time-of-Flight mass spectrometer coupled with nanoElute LC System
The Bruker timsTOF MALDI-2 with nanoElute is an ultra-high performance liquid chromatography-mass spectrometry (UHPLC-MS) and MALDI platform designed for deep proteomics, metabolomics, and spatial-to-solution workflows. By coupling the high-sensitivity timsTOF MALDI-2 mass spectrometer with the robust nanoElute nanoflow LC system, this platform delivers exceptional chromatographic separation, robust CCS-enabled 4D proteomics, and unmatched analytical depth.
Major applications
Proteomics: Comprehensive low-input via robust nanoElute chromatography paired with PASEF acquisition
Biomarker Discovery: High-confidence protein and peptide identification in complex biological matrices
Metabolomics and Lipidomics: In-depth characterization of biological samples using combined mobility separation and post-ionization
Specifications
- • Acquisition modes
- TIMS-MS, DDA-PASEF, DIA-PASEF, and MALDI-2 enhanced imaging/spot analysis
- • Liquid Chromatography System
- nanoElute nanoflow liquid chromatography system engineered for high pressure, ultra-low flow rates, and exceptional retention time reproducibility
- • Acquisition speed
- High-throughput nanoflow proteomics and high-repetition-rate MALDI screening up to 10 kHz
- • Laser technology
- smartbeam 3D laser (up to 10 kHz repetition rate) integrated with MALDI-2 post-ionization technology for enhanced ionization efficiency
- • Separation dimension
- : Trapped Ion Mobility Spectrometry (TIMS) providing Collisional Cross Section (CCS) values for enhanced peak capacity and isomer separation