Nude Mice Room

A nude mice room is a highly sterile, climate-controlled laboratory facility engineered to protect immunodeficient, hairless rodents. Because these mice lack T-cell immune responses and cannot thermoregulate efficiently, the room is kept under positive air pressure with continuous HEPA filtration to eliminate airborne pathogens, while ambient temperatures are elevated to a strict 24°C–28°C. To maximize biosecurity, the mice reside in Individually Ventilated Cages (IVCs) that supply isolated, sterile air directly to each habitat.